DNA Double-Strand Break Repair: An Essential Process for Cell Viability

Subtle Details

DNA double-strand breaks (DSBs) are one of the most toxic lesions that can occur in cells. They can be caused by a variety of factors, including radiation, chemotherapy, and free radicals. If DSBs are not repaired, they can lead to cell death. There are two main pathways for repairing DSBs: homologous recombination (HR) and non-homologous end joining (NHEJ). HR is a more accurate repair pathway, but it is only possible if there is a homologous DNA template available. NHEJ is a less accurate repair pathway, but it can be used to repair DSBs even if there is no homologous DNA template available.

Conclusion

DNA repair is a complex and essential process that keeps our cells healthy and functioning properly. DSB repair is a particularly important process, as DSBs can be caused by a variety of factors and can lead to cell death if not repaired. Understanding the mechanisms of DSB repair is essential for developing new therapies for diseases that are caused by DSBs.